William C Copeland Selected Research

Diffuse Cerebral Sclerosis of Schilder (Alpers' Disease)

3/2013	Alpers-Huttenlocher syndrome.
8/2010	Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations.
7/2009	Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication.
7/2006	Molecular diagnosis of Alpers syndrome.
12/2005	Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome.

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William C Copeland Research Topics

Disease

31	Mitochondrial Diseases (Mitochondrial Disease) 11/2021 - 05/2002
15	Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) 01/2021 - 05/2002
6	Inborn Genetic Diseases (Disease, Hereditary) 01/2016 - 01/2004
6	Ataxia (Dyssynergia) 01/2016 - 12/2003
5	Diffuse Cerebral Sclerosis of Schilder (Alpers' Disease) 03/2013 - 12/2005
3	HIV Infections (HIV Infection) 07/2012 - 05/2003
3	Acquired Immunodeficiency Syndrome (AIDS) 10/2003 - 03/2003
2	Muscle Weakness 01/2021 - 04/2007
2	Liver Failure 01/2018 - 10/2016
2	Cytochrome-c Oxidase Deficiency 01/2017 - 06/2006
2	Neoplasms (Cancer) 11/2016 - 01/2002
2	Infections 01/2010 - 01/2009
1	Ophthalmoplegia (External Ophthalmoplegia) 01/2021
1	Mitochondrial Myopathies (Mitochondrial Myopathy) 01/2021
1	Renal Insufficiency (Renal Failure) 01/2020
1	Macular Degeneration (Age-Related Maculopathy) 01/2020
1	Optic Atrophy 01/2020
1	Muscular Diseases (Myopathy) 01/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017
1	Acute Liver Failure (Fulminant Hepatic Failure) 10/2016
1	Disease Progression 03/2013
1	Premature Aging 06/2012
1	Infantile onset spinocerebellar ataxia 09/2010
1	Genetic Predisposition to Disease (Genetic Predisposition) 06/2009
1	Parkinsonian Disorders (Parkinsonism) 11/2007
1	Bradycardia 04/2007
1	Cardiomyopathies (Cardiomyopathy) 04/2007
1	Liver Diseases (Liver Disease) 07/2006
1	Friedreich Ataxia (Friedreich's Ataxia) 12/2003
1	Hypersensitivity (Allergy) 08/2003
1	Visceral myopathy familial external ophthalmoplegia 06/2003
1	Rare Diseases (Rare Disease) 01/2003
1	Carcinogenesis 01/2002

Drug/Important Bio-Agent (IBA)

35	Mitochondrial DNA (mtDNA)IBA 01/2021 - 01/2002
11	DNA Polymerase gammaIBA 04/2013 - 05/2002
8	DNA (Deoxyribonucleic Acid)IBA 11/2021 - 05/2002
5	NucleosidesIBA 07/2012 - 05/2003
3	Proteins (Proteins, Gene)FDA Link 03/2015 - 01/2010
3	Reverse Transcriptase InhibitorsIBA 07/2012 - 10/2003
2	EnzymesIBA 01/2017 - 03/2013
2	NucleotidesIBA 09/2014 - 01/2012
2	Antiviral Agents (Antivirals)IBA 01/2010 - 05/2003
1	Retinaldehyde (Retinal)IBA 01/2020
1	Aligeron (AS 2)IBA 01/2019
1	Pharmaceutical PreparationsIBA 11/2016
1	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 03/2013
1	TEMPOIBA 03/2013
1	ThymidineIBA 07/2012
1	alovudineIBA 07/2012
1	2',3'- didehydro- 3'- deoxy- 4'- ethynylthymidineIBA 07/2012
1	RecQ HelicasesIBA 06/2012
1	islatravirIBA 03/2012
1	epoxyfarnesyl diazoacetateIBA 03/2012
1	Biomarkers (Surrogate Marker)IBA 08/2010
1	HoloenzymesIBA 06/2009
1	thymidine 5'-triphosphate (thymidine triphosphate)IBA 06/2009
1	8-Hydroxy-2'-DeoxyguanosineIBA 11/2007
1	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 06/2006
1	FrataxinIBA 12/2003
1	IronIBA 12/2003
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 08/2003
1	Phosphotransferases (Kinase)IBA 08/2003
1	NAD (NADH)IBA 08/2003
1	CopperIBA 08/2003
1	2',3'-dideoxy-2',3'-didehydrothymidine monophosphateIBA 05/2003
1	carbovirIBA 05/2003
1	Biological ProductsIBA 03/2003
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2002

Therapy/Procedure

1	Transplantation 01/2020
1	Drug Therapy (Chemotherapy) 11/2016
1	Highly Active Antiretroviral Therapy (HAART) 10/2003
1	Therapeutics 05/2003